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Mouse Proprotein Convertase 9 (PCSK9) ELISA Kit
Mouse Proprotein Convertase 9 (PCSK9) ELISA Kit
This ELISA kit is designed to detect Mouse Proprotein Convertase 9 (Mouse PCSK9). The assay plate has been pre-coated with mouse anti-Mouse PCSK9 monoclonal antibody. When the sample containing PCSK9 is added to the plate, it binds to the antibodies coated on the wells. Then, a horseradish peroxidase conjugated mouse anti-Mouse PCSK9 Antibody is added to the wells and binds to PCSK9 in the sample. After washing the wells, substrate solutions are added, and the color intensity is directly proportional to the amount of Mouse PCSK9 present. The reaction is stopped by adding an acidic stop solution, and the absorbance is measured at 450 nm.
Catalog No:
BPE303
Regular price
$624.00 USD
Regular price
$480.00 USD
Sale price
$624.00 USD
Unit price
/
per
2 weeks
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Product Details
Species Reactivity
Mouse
Sensitivity
36 pg/mL
Detection Range
156.25-10000 pg/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
3.5 hour(s)
Research Areas
Cardiovascular, Cell Biology, Metabolism, Neuroscience, Stem cells, Signal Transduction
Background
Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), which is a newly identified human secretory subtilase belonging to the proteinase K subfamily of the secretory subtilase family. PCSK9 protein is an enzyme which in humans is encoded by the PCSK9 gene with orthologs found across many species. It is expressed in neuroepithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. PCSK9 protein is highly expressed in the liver and regulates low density lipoprotein receptor (LDLR) protein levels. Inhibition of PCSK9 protein function is currently being explored as a means of lowering cholesterol levels. Thereby, PCSK9 protein is regarded as a new strategy to treat hypercholesterolemia. PCSK9 protein contributes to cholesterol homeostasis and may have a role in the differentiation of cortical neurons.
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
This product can be stored at 2-8C.
Analyte
Proprotein convertase subtilisin/kexin type 9
Regulatory Status
For Research Use Only
