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Human C-C Motif Chemokine 20 (CCL20) ELISA Kit
Human C-C Motif Chemokine 20 (CCL20) ELISA Kit
This ELISA kit is designed to detect Human C-C Motif Chemokine 20 (Human CCL20). The assay plate has been pre-coated with mouse anti-Human CCL20 monoclonal antibody. When the sample containing CCL20 is added to the plate, it binds to the antibodies coated on the wells. Then, a horseradish peroxidase conjugated mouse anti-Human CCL20 Antibody is added to the wells and binds to CCL20 in the sample. After washing the wells, substrate solutions are added, and the color intensity is directly proportional to the amount of Human CCL20 present. The reaction is stopped by adding an acidic stop solution, and the absorbance is measured at 450 nm.
Catalog No:
BPE093
Regular price
$624.00 USD
Regular price
$480.00 USD
Sale price
$624.00 USD
Unit price
/
per
2 weeks
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Product Details
Species Reactivity
Human
Sensitivity
1.55 pg/mL
Detection Range
7.81-500 pg/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
3.5 hour(s)
Research Areas
Immunology, Neuroscience, Signal Transduction
Background
Chemokine (C-C motif) ligand 2 (CCL2) or liver activation regulated chemokine (LARC) or Macrophage Inflammatory Protein-3 (MIP3A) is a small cytokine belonging to the CC chemokine family that attracts immature dendritic cells and memory T lymphocytes, both expressing CCR6. Depending on the cell type, this chemokine was found to be inducible by cytokines (IL-1beta) and by bacterial, viral, or plant products (including LPS, dsRNA, and PMA). MIP3A / CCL2 is Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels of MIP3A / CCL2 has been seen in thymus, prostate, testis, small intestine and colon. As a chemotactic factor, MIP3A / CCL2 attracts lymphocytes and, slightly, neutrophils, but not monocytes. This chemokine may Inhibit proliferation of myeloid progenitors in colony formation assays and it may be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Its C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Chemokine CCL2 was shown to play a role in colorectal cancer (CRC) pathogenesis.
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
This product can be stored at 2-8C.
Analyte
C-C motif chemokine 20
Regulatory Status
For Research Use Only
