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Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5) ELISA Kit
Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5) ELISA Kit
This ELISA kit is designed to detect Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (Human CEACAM5). The assay plate has been pre-coated with mouse anti-Human CEACAM5 monoclonal antibody. When the sample containing CEACAM5 is added to the plate, it binds to the antibodies coated on the wells. Then, a horseradish peroxidase conjugated mouse anti-Human CEACAM5 Antibody is added to the wells and binds to CEACAM5 in the sample. After washing the wells, substrate solutions are added, and the color intensity is directly proportional to the amount of Human CEACAM5 present. The reaction is stopped by adding an acidic stop solution, and the absorbance is measured at 450 nm.
Catalog No:
BPE175
Regular price
$624.00 USD
Regular price
$480.00 USD
Sale price
$624.00 USD
Unit price
/
per
2 weeks
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Product Details
Species Reactivity
Human
Sensitivity
24.26 pg/mL
Detection Range
78.13-5000 pg/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
3.5 hour(s)
Research Areas
Cancer, Immunology, Stem cells, Tags and Cell Markers
Background
CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of the immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with an MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domains and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
This product can be stored at 2-8C.
Analyte
Carcinoembryonic antigen-related cell adhesion molecule 5
Regulatory Status
For Research Use Only
