The Human (GABRA1) Gamma-aminobutyric Acid Receptor Subunit Alpha-1 ELISA Kit measures Gamma-aminobutyric acid receptor subunit alpha-1 in samples. The plate has been pre-coated with Human GABRA1 antibody. GABRA1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human GABRA1 Antibody is added and binds to GABRA1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated GABRA1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human GABRA1 . The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
BackgroundLigand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain (PubMed:23909897, PubMed:25489750, PubMed:29950725).
Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel (PubMed:23909897, PubMed:25489750).
The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer (By similarity).
The alpha1/beta2/gamma2 receptor and the alpha1/beta3/gamma2 receptor exhibit synaptogenic activity (PubMed:23909897, PubMed:25489750).
GABRA1-mediated plasticity in the orbitofrontal cortex regulates context-dependent action selection (By similarity).
Functions also as histamine receptor and mediates cellular responses to histamine (By similarity). Source: UniProt Consortium (2025)
