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Human KCND2 (Potassium Voltage-gated Channel Subfamily D Member 2) ELISA Kit
Human KCND2 (Potassium Voltage-gated Channel Subfamily D Member 2) ELISA Kit
The Human (KCND2) Potassium Voltage-gated Channel Subfamily D Member 2 ELISA Kit measures Potassium Voltage-Gated Channel Subfamily D Member 2 in samples. The plate has been pre-coated with Human KCND2 antibody. KCND2 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human KCND2 Antibody is added and binds to KCND2 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated KCND2 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human KCND2. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E4850Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
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2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
8.11 ng/L
Detection Range
15-3000 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Neuroscience
Background
Voltage-gated potassium Channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By similarity). Mediates the transient outward current I(to) in rodent heart left ventricle apex cells, but not in human heart, where this current is mediated by another family member. Forms tetrameric potassium-selective Channels through which potassium ions pass in accordance with their electrochemical gradient (PubMed: 10551270, PubMed: 15454437, PubMed: 14695263, PubMed: 14623880, PubMed: 1$498.00|$360.000201, PubMed: 16934482, PubMed: 24811166, PubMed: 24501278). The Channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed: 11507158). Can form functional homotetrameric Channels and heterotetrameric Channels that contain variable proportions of KCND2 and KCND3; Channel properties depend on the type of pore-forming alpha subunits that are part of the Channel. In vivo, membranes probably contain a mixture of heteromeric potassium Channel complexes. Interaction with specific isoforms of the regulatory subunits KCNIP1, KCNIP2, KCNIP3 or KCNIP4 strongly increases expression at the cell surface and thereby increases Channel activity; it modulates the kinetics of Channel activation and inactivation, shifts the threshold for Channel activation to more negative voltage values, shifts the threshold for inactivation to less negative voltages and accelerates recovery after inactivation (PubMed: 15454437, PubMed: 14623880, PubMed: 1$498.00|$360.000201, PubMed: 19171772, PubMed: 24501278, PubMed: 24811166). Likewise, interaction with DPP6 or DPP10 promotes expression at the cell membrane and regulates both Channel characteristics and activity (By similarity). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Potassium Voltage-Gated Channel Subfamily D Member 2
Regulatory Status
For Research Use Only
