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Human KCNQ1 (Potassium Voltage-gated Channel Subfamily Kqt Member 1) ELISA Kit
Human KCNQ1 (Potassium Voltage-gated Channel Subfamily Kqt Member 1) ELISA Kit
The Human (KCNQ1) Potassium Voltage-gated Channel Subfamily Kqt Member 1 ELISA Kit measures Potassium Voltage-Gated Channel Subfamily Kqt Member 1 in samples. The plate has been pre-coated with Human KCNQ1 antibody. KCNQ1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human KCNQ1 Antibody is added and binds to KCNQ1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated KCNQ1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human KCNQ1. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E4847Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
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2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
7.81 ng/L
Detection Range
15-3000 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Background
Potassium Channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (PubMed: 10646604, PubMed: 25441029). Associates with KCNE beta subunits that modulates current kinetics (PubMed: 9312006, PubMed: 9108097, PubMed: 8900283, PubMed: 10646604, PubMed: 11101505, PubMed: 19687231). Induces a voltage-dependent current by rapidly activating and slowly deactivating potassium-selective outward current (PubMed: 9312006, PubMed: 9108097, PubMed: 8900283, PubMed: 10646604, PubMed: 11101505, PubMed: 25441029). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed: 9312006, PubMed: 9108097, PubMed: 8900283, PubMed: 10646604, PubMed: 11101505). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (PubMed: 10713961). When associated with KCNE3, forms the potassium Channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (PubMed: 10646604). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (By similarity). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (By similarity). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed: 11101505). When associated with KCNE4, inhibits voltage-gated potassium Channel activity (PubMed: 19687231). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (PubMed: 12324418). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium Channel activity (PubMed: 24855057). Binds with phosphatidylinositol 4,5-bisphosphate (PubMed: 25037568). [Isoform 2]: Non-functional alone but modulatory when coexpressed with the full-length isoform 1. Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Potassium Voltage-Gated Channel Subfamily Kqt Member 1
Regulatory Status
For Research Use Only
