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Human Lysosome-Associated Membrane Glycoprotein 3 (LAMP3) ELISA Kit
Human Lysosome-Associated Membrane Glycoprotein 3 (LAMP3) ELISA Kit
This ELISA kit is designed to detect Human Lysosome-Associated Membrane Glycoprotein 3 (Human LAMP3). The assay plate has been pre-coated with mouse anti-Human LAMP3 monoclonal antibody. When the sample containing LAMP3 is added to the plate, it binds to the antibodies coated on the wells. Then, a horseradish peroxidase conjugated mouse anti-Human LAMP3 Antibody is added to the wells and binds to LAMP3 in the sample. After washing the wells, substrate solutions are added, and the color intensity is directly proportional to the amount of Human LAMP3 present. The reaction is stopped by adding an acidic stop solution, and the absorbance is measured at 450 nm.
Catalog No:
BPE104
Regular price
$754.00 USD
Regular price
$580.00 USD
Sale price
$754.00 USD
Unit price
/
per
2 weeks
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Product Details
Species Reactivity
Human
Sensitivity
7.55 pg/mL
Detection Range
31.25-2000 pg/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
3.5 hour(s)
Research Areas
Cancer, Stem cells, Tags and Cell Markers
Background
Dendritic cell-lysosomal associated membrane protein (DC-LAMP)/CD208, also known as LAMP3, is a member of the lysosomal associated membrane protein (LAMP) family, which is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as a marker of human DC maturation. Confocal and immunoelectron microscopy showed that mouse DC-LAMP protein co-localizes with lbm180, a specific marker for the limiting membrane of lamellar bodies that contain surfactant protein B. The present study demonstrates that DC-LAMP is constitutively expressed by mouse, sheep, and human type II pneumocytes. DC-LAMP is constitutively expressed in normal type II pneumocytes. DC-LAMP is detected first in the activated human DC within MHC class II molecules-containing compartments just before the translocation of MHC class II-peptide complexes to the cell surface, suggesting a possible involvement in this process. Furthermore, overexpression of LAMP3 is actively involved in tumor invasion through increased migration into lymph-vascular spaces.
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
This product can be stored at 2-8C.
Analyte
Lysosome-associated membrane glycoprotein 3
Regulatory Status
For Research Use Only
