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Human MASP1 (Mannan-binding Lectin Serine Peptidase 1) ELISA Kit
Human MASP1 (Mannan-binding Lectin Serine Peptidase 1) ELISA Kit
The Human (MASP1) Mannan-binding Lectin Serine Peptidase 1 ELISA Kit measures Mannan-Binding Lectin Serine Peptidase 1 in samples. The plate has been pre-coated with Human MASP1 antibody. MASP1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human MASP1 Antibody is added and binds to MASP1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated MASP1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human MASP1. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E5632Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
0.58 ng/mL
Detection Range
1-400 ng/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Immunology
Background
Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed: 21258343). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Mannan-Binding Lectin Serine Peptidase 1
Regulatory Status
For Research Use Only
