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Human MXRA8 (Matrix-Remodeling-associated Protein 8) ELISA Kit
Human MXRA8 (Matrix-Remodeling-associated Protein 8) ELISA Kit
The Human (MXRA8) Matrix-Remodeling-associated Protein 8 ELISA Kit measures Matrix-Remodeling-Associated Protein 8 in samples. The plate has been pre-coated with Human MXRA8 antibody. MXRA8 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human MXRA8 Antibody is added and binds to MXRA8 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated MXRA8 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human MXRA8. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E5650Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
0.026 ng/mL
Detection Range
0.05-20 ng/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Cell Biology
Background
Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed: 22492581, PubMed: 23386276). Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By similarity). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (By similarity). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (PubMed: 23386276). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (PubMed: 23386276). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (PubMed: 23386276). May play a role in the maturation and maintenance of the blood-brain barrier (By similarity). (Microbial infection) Contributes to arthritogenic alphavirus pathogenesis and acts as a receptor for these viruses. Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Matrix-Remodeling-Associated Protein 8
Regulatory Status
For Research Use Only
