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Human NGAL (Neutrophil Gelatinase-associated Lipocalin) ELISA Kit
Human NGAL (Neutrophil Gelatinase-associated Lipocalin) ELISA Kit
The Human (NGAL) Neutrophil Gelatinase-associated Lipocalin ELISA Kit measures Neutrophil Gelatinase-Associated Lipocalin in samples.
Catalog No:
E1719Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
2.01 ng/mL
Detection Range
5-600 ng/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Metabolism, Kidney biomarker
Background
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed: 12453413, PubMed: 27780864, PubMed: 20581821). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed: 27780864). Can also bind siderophores from M.tuberculosis (PubMed: 15642259, PubMed: 21978368). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Neutrophil Gelatinase-Associated Lipocalin
Regulatory Status
For Research Use Only
