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Human OLAB (Anti-oxidized Low Density Lipoprotein Antibody) ELISA Kit
Human OLAB (Anti-oxidized Low Density Lipoprotein Antibody) ELISA Kit
The Human (OLAB) Anti-oxidized Low Density Lipoprotein Antibody ELISA Kit measures Anti-Oxidized Low Density Lipoprotein Antibody in samples. The plate has been pre-coated with Human OLAb antibody. OLAb present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human OLAb Antibody is added and binds to OLAb in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated OLAb antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human OLAb. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2295Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
0.5 ng/mL
Detection Range
1-300 ng/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Immunology, Autoimmunity
Background
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria. Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Anti-Oxidized Low Density Lipoprotein Antibody
Regulatory Status
For Research Use Only
