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Human Receptor Tyrosine-Protein Kinase Erbb-2 (ERBB2) ELISA Kit
Human Receptor Tyrosine-Protein Kinase Erbb-2 (ERBB2) ELISA Kit
This ELISA kit is designed to detect Human Receptor Tyrosine-Protein Kinase Erbb-2 (Human ERBB2). The assay plate has been pre-coated with mouse anti-Human Her2 monoclonal antibody. When the sample containing Her2 is added to the plate, it binds to the antibodies coated on the wells. Then, a horseradish peroxidase conjugated mouse anti-Human Her2 Antibody is added to the wells and binds to Her2 in the sample. After washing the wells, substrate solutions are added, and the color intensity is directly proportional to the amount of Human Her2 present. The reaction is stopped by adding an acidic stop solution, and the absorbance is measured at 450 nm.
Catalog No:
BPE368
Regular price
$624.00 USD
Regular price
$480.00 USD
Sale price
$624.00 USD
Unit price
/
per
2 weeks
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Product Details
Species Reactivity
Human
Sensitivity
7.59 pg/mL
Detection Range
24-1500 pg/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
3.5 hour(s)
Research Areas
Cancer, Neuroscience, Signal Transduction, Tags and Cell Markers
Background
Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
This product can be stored at 2-8C.
Analyte
Receptor tyrosine-protein kinase erbB-2
Regulatory Status
For Research Use Only
