The Bovine (TREM-1) Triggering Receptor Expresses On Myeloid Cells-1 ELISA Kit measures Triggering Receptor Expresses On Myeloid Cells-1 in Bovine samples. The plate has been pre-coated with Bovine TREM1 antibody. TREM1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Bovine TREM1 Antibody is added and binds to TREM1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated TREM1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Bovine TREM1. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
BackgroundCell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses. Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12. In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma. This cascade promotes the neutrophil- and macrophage-mediated release of proinflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections. By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis. Source: UniProt Consortium (2025)
Shipping ConditionShipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
AnalyteTriggering Receptor Expresses On Myeloid Cells-1
