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Human AUTS2 (Autism Susceptibility Gene 2 Protein) ELISA Kit
Human AUTS2 (Autism Susceptibility Gene 2 Protein) ELISA Kit
The Human (AUTS2) Autism Susceptibility Gene 2 Protein ELISA Kit measures Autism Susceptibility Gene 2 Protein in samples. The plate has been pre-coated with Human AUTS2 antibody. AUTS2 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human AUTS2 Antibody is added and binds to AUTS2 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated AUTS2 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human AUTS2. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E4423Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
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per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
4.62 ng/L
Detection Range
10-3000 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Background
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed: 25519132). The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B (PubMed: 25519132). As a consequence, the complex mediates transcriptional activation (PubMed: 25519132). In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Autism Susceptibility Gene 2 Protein
Regulatory Status
For Research Use Only
