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Human BMP-6 (Bone Morphogenetic Protein 6) ELISA Kit
Human BMP-6 (Bone Morphogenetic Protein 6) ELISA Kit
The Human (BMP-6) Bone Morphogenetic Protein 6 ELISA Kit measures Bone Morphogenetic Protein 6 in samples. The plate has been pre-coated with Human BMP-6 antibody. BMP-6 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human BMP-6 Antibody is added and binds to BMP-6 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated BMP-6 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human BMP-6. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E1480Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
0.23 mg/L
Detection Range
0.5-150 mg/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Signal Transduction, Cell Biology, Stem Cells, Bone Metabolism
Background
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (PubMed:31019025).
Plays also an important role in the regulation of iron metabolism by acting as a ligand for hemojuvelin/HJV (By similarity).
Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B (PubMed:18070108).
In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (PubMed:33021694). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Bone Morphogenetic Protein 6
Regulatory Status
For Research Use Only
