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Human BMP5 (Bone Morphogenetic Protein 5) ELISA Kit
Human BMP5 (Bone Morphogenetic Protein 5) ELISA Kit
The Human (BMP5) Bone Morphogenetic Protein 5 ELISA Kit measures Bone Morphogenetic Protein 5 in samples. The plate has been pre-coated with Human BMP5 antibody. BMP5 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human BMP5 Antibody is added and binds to BMP5 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated BMP5 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human BMP5. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2244Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
4.88 ng/L
Detection Range
10-2000 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Cardiovascular, Signal Transduction, Cell Biology, Bone Metabolism
Background
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:11580864, PubMed:29321139).
Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:11580864).
In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:29321139, PubMed:11580864).
Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed:20402566). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Bone Morphogenetic Protein 5
Regulatory Status
For Research Use Only
