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Human BST2 (Bone Marrow Stromal Antigen 2) ELISA Kit
Human BST2 (Bone Marrow Stromal Antigen 2) ELISA Kit
The Human (BST2) Bone Marrow Stromal Antigen 2 ELISA Kit measures Bone Marrow Stromal Antigen 2 in samples. The plate has been pre-coated with Human BST2 antibody. BST2 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human BST2 Antibody is added and binds to BST2 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated BST2 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human BST2. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E6560Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
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2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
4.72 ng/L
Detection Range
10-2000 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Bone Metabolism
Background
IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted (PubMed: 22520941, PubMed: 21529378, PubMed: 20940320, PubMed: 20419159, PubMed: 20399176, PubMed: 19879838, PubMed: 19036818, PubMed: 18342597, PubMed: 18200009). Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), human immunodeficiency virus type 2 (HIV-2), simian immunodeficiency viruses (SIVs), equine infectious anemia virus (EIAV), feline immunodeficiency virus (FIV), prototype foamy virus (PFV), Mason-Pfizer monkey virus (MPMV), human T-cell leukemia virus type 1 (HTLV-1), Rous sarcoma virus (RSV) and murine leukemia virus (MLV), flavivirideae: hepatitis C virus (HCV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), arenaviridae: lassa virus (LASV) and machupo virus (MACV), herpesviridae: kaposis sarcoma-associated herpesvirus (KSHV), rhabdoviridae: vesicular stomatitis virus (VSV), orthomyxoviridae: influenza A virus, paramyxoviridae: nipah virus, and coronaviridae: SARS-CoV (PubMed: 22520941, PubMed: 21621240, PubMed: 21529378, PubMed: 20943977, PubMed: 20686043, PubMed: 20419159, PubMed: 20399176, PubMed: 19879838, PubMed: 19179289, PubMed: 18342597, PubMed: 18200009, PubMed: 26378163, PubMed: 31199522). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration (PubMed: 22065321). Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (PubMed: 19564354, PubMed: 26172439). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Isoform 1 and isoform 2 are both effective viral restriction factors but have differing antiviral and signaling activities (PubMed: 23028328, PubMed: 26172439). Isoform 2 is resistant to HIV-1 Vpu-mediated degradation and restricts HIV-1 viral budding in the presence of Vpu (PubMed: 23028328, PubMed: 26172439). Isoform 1 acts as an activator of NF-kappa-B and this activity is inhibited by isoform 2 (PubMed: 23028328). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Bone Marrow Stromal Antigen 2
Regulatory Status
For Research Use Only
