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Human CBX3 (Chromobox Protein Homolog 3) ELISA Kit
Human CBX3 (Chromobox Protein Homolog 3) ELISA Kit
The Human (CBX3) Chromobox Protein Homolog 3 ELISA Kit measures Chromobox protein homolog 3 in samples. The plate has been pre-coated with Human CBX3 antibody. CBX3 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human CBX3 Antibody is added and binds to CBX3 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated CBX3 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human CBX3. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2895Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
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per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
2.22 ng/L
Detection Range
5-1000 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Epigenetics and Nuclear Signaling
Background
Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Chromobox protein homolog 3
Regulatory Status
For Research Use Only
