The Human (CCDC134) Coiled-Coil Domain-containing Protein 134 ELISA Kit measures Coiled-Coil Domain-Containing Protein 134 in samples. The plate has been pre-coated with Human CCDC134 antibody. CCDC134 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human CCDC134 Antibody is added and binds to CCDC134 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated CCDC134 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human CCDC134. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
BackgroundIn extracellular secreted form, promotes proliferation and activation of CD8(+) T cells, suggesting a cytokine-like function (PubMed: 25125657). Enhances cytotoxic anti-tumor activity of CD8(+) T cells (PubMed: 25125657). May inhibit ERK and JNK signaling activity (PubMed: 18087676, PubMed: 23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed: 23070808). In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage. Source: UniProt Consortium (2025)
