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Human Collagen Triple Helix Repeat-Containing Protein 1 (CTHRC1) ELISA Kit
Human Collagen Triple Helix Repeat-Containing Protein 1 (CTHRC1) ELISA Kit
This ELISA kit is designed to detect Human Collagen Triple Helix Repeat-Containing Protein 1 (Human CTHRC1). The assay plate has been pre-coated with mouse anti-Human CTHRC1 monoclonal antibody. When the sample containing CTHRC1 is added to the plate, it binds to the antibodies coated on the wells. Then, a horseradish peroxidase conjugated mouse anti-Human CTHRC1 Antibody is added to the wells and binds to CTHRC1 in the sample. After washing the wells, substrate solutions are added, and the color intensity is directly proportional to the amount of Human CTHRC1 present. The reaction is stopped by adding an acidic stop solution, and the absorbance is measured at 450 nm.
Catalog No:
BPE212
Regular price
$754.00 USD
Regular price
$580.00 USD
Sale price
$754.00 USD
Unit price
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per
2 weeks
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Product Details
Species Reactivity
Human
Sensitivity
14.84 pg/mL
Detection Range
46.88-3000 pg/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
3.5 hour(s)
Research Areas
Cancer, Cardiovascular, Signal Transduction
Background
Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the CTHRC1 protein and this renders the molecule susceptible to cleavage by collagenase. CTHRC1 overexpression caused a dramatic reduction in collagen type I mRNA and protein levels. Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including collagens. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis.
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
This product can be stored at 2-8C.
Analyte
Collagen triple helix repeat-containing protein 1
Regulatory Status
For Research Use Only
