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Human CXCR3 (C-X-C Chemokine Receptor Type 3) ELISA Kit
Human CXCR3 (C-X-C Chemokine Receptor Type 3) ELISA Kit
The Human (CXCR3) C-X-C Chemokine Receptor Type 3 ELISA Kit measures C-X-C Chemokine Receptor Type 3 in samples. The plate has been pre-coated with Human CXCR3 antibody. CXCR3 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human CXCR3 Antibody is added and binds to CXCR3 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated CXCR3 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human CXCR3. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E7269Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
0.31 ng/mL
Detection Range
0.5-150 ng/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Immunology
Background
[Isoform 1]: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed: 12782716). Binds to CCL21. Probably promotes cell chemotaxis response. [Isoform 2]: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed: 12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. [Isoform 3]: Mediates the activity of CXCL11. Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
C-X-C Chemokine Receptor Type 3
Regulatory Status
For Research Use Only
