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Human Dickkopf-Related Protein 1 (DKK1) ELISA Kit
Human Dickkopf-Related Protein 1 (DKK1) ELISA Kit
This ELISA kit is designed to detect Human Dickkopf-Related Protein 1 (Human DKK1). The assay plate has been pre-coated with mouse anti-Human DKK1 monoclonal antibody. When the sample containing DKK1 is added to the plate, it binds to the antibodies coated on the wells. Then, a horseradish peroxidase conjugated mouse anti-Human DKK1 Antibody is added to the wells and binds to DKK1 in the sample. After washing the wells, substrate solutions are added, and the color intensity is directly proportional to the amount of Human DKK1 present. The reaction is stopped by adding an acidic stop solution, and the absorbance is measured at 450 nm.
Catalog No:
BPE370
Regular price
$624.00 USD
Regular price
$480.00 USD
Sale price
$624.00 USD
Unit price
/
per
2 weeks
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Product Details
Species Reactivity
Human
Sensitivity
7.92 pg/mL
Detection Range
39.06-2500 pg/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
3.5 hour(s)
Research Areas
Cardiovascular, Developmental Biology, Immunology, Stem cells
Background
Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
This product can be stored at 2-8C.
Analyte
Dickkopf-related protein 1
Regulatory Status
For Research Use Only
