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Human Disintegrin And Metalloproteinase Domain-Containing Protein 15 (ADAM15) ELISA Kit
Human Disintegrin And Metalloproteinase Domain-Containing Protein 15 (ADAM15) ELISA Kit
This ELISA kit is designed to detect Human Disintegrin And Metalloproteinase Domain-Containing Protein 15 (Human ADAM15). The assay plate has been pre-coated with mouse anti-Human ADAM15 monoclonal antibody. When the sample containing ADAM15 is added to the plate, it binds to the antibodies coated on the wells. Then, a horseradish peroxidase conjugated mouse anti-Human ADAM15 Antibody is added to the wells and binds to ADAM15 in the sample. After washing the wells, substrate solutions are added, and the color intensity is directly proportional to the amount of Human ADAM15 present. The reaction is stopped by adding an acidic stop solution, and the absorbance is measured at 450 nm.
Catalog No:
BPE102
Regular price
$624.00 USD
Regular price
$480.00 USD
Sale price
$624.00 USD
Unit price
/
per
2 weeks
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Product Details
Species Reactivity
Human
Sensitivity
10.75 pg/mL
Detection Range
46.88-3000 pg/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
3.5 hour(s)
Research Areas
Cancer, Cell Biology, Signal Transduction
Background
ADAM15, also known as Metargidin, is a type I transmembrane glycoprotein belonging to the ADAM (A Disintegrin and Metalloprotease Domain) family of proteins and is widely expressed in different tissues and cell types. Members of this family contain an amino-terminal metalloprotease domain followed by a disintegrin domain, a cysteine-rich region and a membrane proximal EGF-like domain. The disintegrin domain of ADAM15/metargidin contains an RGD tripeptide sequence, suggesting that it may potentially interact with the integrin family of proteins. ADAM15 is a transmembrane multi-domain proteins implicated in proteolysis, cell-cell and cell-matrix interactions in various disease conditions. There is also evidence supporting a role for ADAM15 in angiogenesis and angioinvasion of tumor cells, which are critical for unrestrained tumor growth and metastatic spread. Given its diverse functions, ADAM15 may represent a pivotal regulatory component of tumor progression, an important target for therapeutic intervention, or emerge as a biomarker of disease progression.
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
This product can be stored at 2-8C.
Analyte
Disintegrin and metalloproteinase domain-containing protein 15
Regulatory Status
For Research Use Only
