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Human FUR (Furin) ELISA Kit
Human FUR (Furin) ELISA Kit
The Human (FUR) Furin ELISA Kit measures Furin in samples. The plate has been pre-coated with Human FURIN antibody. FURIN present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human FURIN Antibody is added and binds to FURIN in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated FURIN antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human FURIN. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2321Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
6.93 ng/L
Detection Range
15-3000 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Cell Biology
Background
Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed: 11799113, PubMed: 1629222, PubMed: 1713771, PubMed: 2251280, PubMed: 24666235, PubMed: 25974265, PubMed: 7592877, PubMed: 7690548, PubMed: 9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed: 7737999). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32) (PubMed: 20489134, PubMed: 21763278). (Microbial infection) Probably cleaves and activates anthrax and diphtheria toxins. (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin. (Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP. (Microbial infection) Facilitates human coronaviruses EMC and SARS-CoV-2 infections by proteolytically cleaving the spike protein at the monobasic S1/S2 cleavage site. This cleavage is essential for spike protein-mediated cell-cell fusion and entry into human lung cells. Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Furin
Regulatory Status
For Research Use Only
