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Human FZD7 (Frizzled-7) ELISA Kit
Human FZD7 (Frizzled-7) ELISA Kit
The Human (FZD7) Frizzled-7 ELISA Kit measures Frizzled-7 in samples. The plate has been pre-coated with Human FZD7 antibody. FZD7 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human FZD7 Antibody is added and binds to FZD7 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated FZD7 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human FZD7. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2363Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
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per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
0.013 ng/mL
Detection Range
0.05-15 ng/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Background
Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes (By similarity).
Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses (PubMed:26126266).
May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
(Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium. Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Frizzled-7
Regulatory Status
For Research Use Only
