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Human Granulocyte Colony-Stimulating Factor Receptor (CSF3R) ELISA Kit
Human Granulocyte Colony-Stimulating Factor Receptor (CSF3R) ELISA Kit
This ELISA kit is designed to detect Human Granulocyte Colony-Stimulating Factor Receptor (Human CSF3R). The assay plate has been pre-coated with mouse anti-Human CSF3R monoclonal antibody. When the sample containing CSF3R is added to the plate, it binds to the antibodies coated on the wells. Then, a horseradish peroxidase conjugated mouse anti-Human CSF3R Antibody is added to the wells and binds to CSF3R in the sample. After washing the wells, substrate solutions are added, and the color intensity is directly proportional to the amount of Human CSF3R present. The reaction is stopped by adding an acidic stop solution, and the absorbance is measured at 450 nm.
Catalog No:
BPE048
Regular price
$624.00 USD
Regular price
$480.00 USD
Sale price
$624.00 USD
Unit price
/
per
2 weeks
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Product Details
Species Reactivity
Human
Sensitivity
11.34 pg/mL
Detection Range
50-3200 pg/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
3.5 hour(s)
Research Areas
Cancer, Immunology, Stem cells
Background
Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
This product can be stored at 2-8C.
Analyte
Granulocyte colony-stimulating factor receptor
Regulatory Status
For Research Use Only
