The Human (KCNAB2) Voltage Gated Potassium Channel Subunit Beta-2 ELISA Kit measures Voltage Gated Potassium Channel Subunit Beta-2 in samples. The plate has been pre-coated with Human KCNAB2 antibody. KCNAB2 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human KCNAB2 Antibody is added and binds to KCNAB2 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated KCNAB2 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human KCNAB2. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
BackgroundCytoplasmic potassium Channel subunit that modulates the characteristics of the Channel-forming alpha-subunits (PubMed: 7649300, PubMed: 11825900). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity). Promotes expression of the pore-forming alpha subunits at the cell membrane, and thereby increases Channel activity (By similarity). Promotes potassium Channel closure via a mechanism that does not involve physical obstruction of the Channel pore (PubMed: 7649300, PubMed: 11825900). Promotes KCNA4 Channel closure (PubMed: 7649300, PubMed: 11825900). Modulates the functional properties of KCNA5 (By similarity). Enhances KCNB2 Channel activity (By similarity). Binds NADPH and has NADPH-dependent aldoketoreductase activity (By similarity). Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) (By similarity). Source: UniProt Consortium (2025)
