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Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 (LILRB3) ELISA Kit
Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 (LILRB3) ELISA Kit
This ELISA kit is designed to detect Human Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 (Human LILRB3). The assay plate has been pre-coated with mouse anti-Human LILRB3 monoclonal antibody. When the sample containing LILRB3 is added to the plate, it binds to the antibodies coated on the wells. Then, a horseradish peroxidase conjugated mouse anti-Human LILRB3 Antibody is added to the wells and binds to LILRB3 in the sample. After washing the wells, substrate solutions are added, and the color intensity is directly proportional to the amount of Human LILRB3 present. The reaction is stopped by adding an acidic stop solution, and the absorbance is measured at 450 nm.
Catalog No:
BPE237
Regular price
$754.00 USD
Regular price
$580.00 USD
Sale price
$754.00 USD
Unit price
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per
2 weeks
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Product Details
Species Reactivity
Human
Sensitivity
17.17 pg/mL
Detection Range
78.125-5000 pg/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
3.5 hour(s)
Research Areas
Immunology
Background
Leukocyte immunoglobulin-like receptor subfamily B member 3, also known as Leukocyte immunoglobulin-like receptor 3, Immunoglobulin-like transcript 5, Monocyte inhibitory receptor HL9, CD85 antigen-like family member A, CD85a and LILRB3, is a single-pass type I membrane protein that belongs to the leukocyte receptor cluster (LRC) present on 19q13.4. LILRB3 / CD85a contains four Ig-like C2-type (immunoglobulin-like) domains. LILRB3 / CD85a contains three copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in the modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. LILRB3 / CD85a is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found.
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
This product can be stored at 2-8C.
Analyte
Leukocyte immunoglobulin-like receptor subfamily B member 3
Regulatory Status
For Research Use Only
