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Human Npc Intracellular Cholesterol Transporter 2 (NPC2) ELISA Kit
Human Npc Intracellular Cholesterol Transporter 2 (NPC2) ELISA Kit
This ELISA kit is designed to detect Human Npc Intracellular Cholesterol Transporter 2 (Human NPC2). The assay plate has been pre-coated with mouse anti-Human NPC2 monoclonal antibody. When the sample containing NPC2 is added to the plate, it binds to the antibodies coated on the wells. Then, a horseradish peroxidase conjugated mouse anti-Human NPC2 Antibody is added to the wells and binds to NPC2 in the sample. After washing the wells, substrate solutions are added, and the color intensity is directly proportional to the amount of Human NPC2 present. The reaction is stopped by adding an acidic stop solution, and the absorbance is measured at 450 nm.
Catalog No:
BPE270
Regular price
$754.00 USD
Regular price
$580.00 USD
Sale price
$754.00 USD
Unit price
/
per
2 weeks
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Product Details
Species Reactivity
Human
Sensitivity
41.67 pg/mL
Detection Range
156.25-10000 pg/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
3.5 hour(s)
Research Areas
Cardiovascular, Neuroscience, Metabolism, Signal Transduction
Background
Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. NPC2 is a small lysosomal glycoprotein that binds cholesterol with submicromolar affinity. Deficiency in NPC2 is the cause of Niemann-Pick type C2 disease, a fatal neurovisceral disorder characterized by the accumulation of cholesterol in lysosomes. Niemann-Pick disease, type C2 (NPC2) protein is one of the most abundant components of the epididymal fluid and contains a functional cholesterol-binding site that can transfer cholesterol between membranes, it has been suggested for years that NPC2 could be involved in the regulation of cholesterol levels in spermatozoa during epididymal maturation.
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
This product can be stored at 2-8C.
Analyte
NPC intracellular cholesterol transporter 2
Regulatory Status
For Research Use Only
