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Human RTN4R (Reticulon-4 Receptor) ELISA Kit
Human RTN4R (Reticulon-4 Receptor) ELISA Kit
The Human (RTN4R) Reticulon-4 Receptor ELISA Kit measures Reticulon-4 Receptor in samples. The plate has been pre-coated with Human RTN4R antibody. RTN4R present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human RTN4R Antibody is added and binds to RTN4R in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated RTN4R antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human RTN4R. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E6081Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
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per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
9.69 ng/L
Detection Range
20-3500 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Background
Receptor for RTN4, OMG and MAG (PubMed: 12037567, PubMed: 12068310, PubMed: 12426574, PubMed: 12089450, PubMed: 16712417, PubMed: 18411262, PubMed: 12839991, PubMed: 19052207). Functions as receptor for the sialylated gangliosides GT1b and GM1 (PubMed: 18411262). Besides, functions as receptor for chondroitin sulfate proteoglycans (By similarity). Can also bind heparin (By similarity). Intracellular signaling cascades are triggered via the coreceptor NGFR (PubMed: 12426574). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed: 16712417, PubMed: 22325200). Mediates axonal growth inhibition (PubMed: 12839991, PubMed: 19052207, PubMed: 28892071). Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed: 22325200). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Reticulon-4 Receptor
Regulatory Status
For Research Use Only
