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Human SACM1L (Phosphatidylinositide Phosphatase Sac1) ELISA Kit
Human SACM1L (Phosphatidylinositide Phosphatase Sac1) ELISA Kit
The Human (SACM1L) Phosphatidylinositide Phosphatase Sac1 ELISA Kit measures Phosphatidylinositide phosphatase SAC1 in samples. The plate has been pre-coated with Human SACM1L antibody. SACM1L present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human SACM1L Antibody is added and binds to SACM1L in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated SACM1L antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human SACM1L. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E5864Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
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per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
5.37 ng/L
Detection Range
10-2000 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Signal Transduction, Enzyme & Kinase
Background
Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869669).
Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669).
Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895).
Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455).
Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity).
May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Phosphatidylinositide phosphatase SAC1
Regulatory Status
For Research Use Only
