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Human SCIN (Adseverin) ELISA Kit
Human SCIN (Adseverin) ELISA Kit
The Human (SCIN) Adseverin ELISA Kit measures Adseverin in samples. The plate has been pre-coated with Human SCIN antibody. SCIN present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human SCIN Antibody is added and binds to SCIN in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated SCIN antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human SCIN. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E6742Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
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per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
10.18 ng/L
Detection Range
20-4500 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Signal Transduction
Background
Ca2+-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane (PubMed:8547642, PubMed:26365202).
Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity).
In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (PubMed:11568009).
Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity).
Regulates chondrocyte proliferation and differentiation (By similarity).
Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (PubMed:11568009). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Adseverin
Regulatory Status
For Research Use Only
