The Human (SCYE1) Aminoacyl Trna Synthase Complex-interacting Multifunctional Protein 1 ELISA Kit measures Aminoacyl tRNA Synthase complex-interacting multifunctional protein 1 in samples. The plate has been pre-coated with Human SCYE1 antibody. SCYE1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human SCYE1 Antibody is added and binds to SCYE1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated SCYE1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human SCYE1. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
BackgroundNon-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004).
Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575).
Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity).
Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity).
Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771).
Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity).
Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313).
Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442).
Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550). Source: UniProt Consortium (2025)
Shipping ConditionShipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
AnalyteAminoacyl tRNA Synthase complex-interacting multifunctional protein 1
