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Human SDCBP (Syntenin-1) ELISA Kit
Human SDCBP (Syntenin-1) ELISA Kit
The Human (SDCBP) Syntenin-1 ELISA Kit measures Syntenin-1 in samples. The plate has been pre-coated with Human SDCBP antibody. SDCBP present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human SDCBP Antibody is added and binds to SDCBP in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated SDCBP antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human SDCBP. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E4148hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
0.02 ng/mL
Detection Range
0.05-15 ng/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Background
Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed: 26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed: 25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed: 22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed: 26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed: 11$498.00|$360.00591). May also play a role in vesicular trafficking (PubMed: 11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed: 10230395). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Syntenin-1
Regulatory Status
For Research Use Only
