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Human SLAMF7 (Slam Family Member 7) ELISA Kit
Human SLAMF7 (Slam Family Member 7) ELISA Kit
The Human (SLAMF7) Slam Family Member 7 ELISA Kit measures Slam Family Member 7 in samples. The plate has been pre-coated with Human SLAMF7 antibody. SLAMF7 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human SLAMF7 Antibody is added and binds to SLAMF7 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated SLAMF7 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human SLAMF7. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E6179Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
14.56 ng/L
Detection Range
30-9000 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Immunology
Background
Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed: 11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed: 16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed: 11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed: 23695528). Isoform 3 does not mediate any NK cell activation. Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Slam Family Member 7
Regulatory Status
For Research Use Only
