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Human SMURF1 (E3 Ubiquitin-protein Ligase Smurf1) ELISA Kit
Human SMURF1 (E3 Ubiquitin-protein Ligase Smurf1) ELISA Kit
The Human (SMURF1) E3 Ubiquitin-protein Ligase Smurf1 ELISA Kit measures E3 ubiquitin-protein ligase SMURF1 in samples. The plate has been pre-coated with Human SMURF1 antibody. SMURF1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human SMURF1 Antibody is added and binds to SMURF1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated SMURF1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human SMURF1. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E6630Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
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per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
12.28 ng/L
Detection Range
20-4500 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Cell Biology, Immunology
Background
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404).
Plays a role in dendrite formation by melanocytes (PubMed:23999003). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
E3 ubiquitin-protein ligase SMURF1
Regulatory Status
For Research Use Only
