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Human SNX2 (Sorting Nexin 2) ELISA Kit
Human SNX2 (Sorting Nexin 2) ELISA Kit
The Human (SNX2) Sorting Nexin 2 ELISA Kit measures Sorting Nexin 2 in samples. The plate has been pre-coated with Human SNX2 antibody. SNX2 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human SNX2 Antibody is added and binds to SNX2 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated SNX2 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human SNX2. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2548Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
14.14 ng/L
Detection Range
25-5000 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Background
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed: 16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed: 17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed: 23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed: 20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed: 20604901). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Sorting Nexin 2
Regulatory Status
For Research Use Only
