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Human SOCS1 (Suppressors of Cytokine Signaling 1) ELISA Kit
Human SOCS1 (Suppressors of Cytokine Signaling 1) ELISA Kit
The Human (SOCS1) Suppressors of Cytokine Signaling 1 ELISA Kit measures Suppressors of Cytokine Signaling 1 in samples. The plate has been pre-coated with Human SOCS1 antibody. SOCS1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human SOCS1 Antibody is added and binds to SOCS1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated SOCS1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human SOCS1. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2960Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
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per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
0.102 ng/mL
Detection Range
0.2-60 ng/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Background
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway. Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Suppressors of Cytokine Signaling 1
Regulatory Status
For Research Use Only
