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Human SYT11 (Synaptotagmin 11) ELISA Kit
Human SYT11 (Synaptotagmin 11) ELISA Kit
The Human (SYT11) Synaptotagmin 11 ELISA Kit measures Synaptotagmin 11 in samples. The plate has been pre-coated with Human SYT11 antibody. SYT11 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Human SYT11 Antibody is added and binds to SYT11 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated SYT11 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Human SYT11. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2573Hu
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Human
Sensitivity
0.022 ng/mL
Detection Range
0.05-10 ng/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Neuroscience
Background
Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca2+. Inhibits clathrin-mediated and bulk endocytosis, functions to ensure precision in vesicle retrieval. Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process. Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity).
Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (PubMed:27278822). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Synaptotagmin 11
Regulatory Status
For Research Use Only
