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Human Xaa-Pro Aminopeptidase 2 (XPNPEP2) ELISA Kit
Human Xaa-Pro Aminopeptidase 2 (XPNPEP2) ELISA Kit
This ELISA kit is designed to detect Human Xaa-Pro Aminopeptidase 2 (Human XPNPEP2). The assay plate has been pre-coated with mouse anti-Human XPNPEP2 monoclonal antibody. When the sample containing XPNPEP2 is added to the plate, it binds to the antibodies coated on the wells. Then, a horseradish peroxidase conjugated mouse anti-Human XPNPEP2 Antibody is added to the wells and binds to XPNPEP2 in the sample. After washing the wells, substrate solutions are added, and the color intensity is directly proportional to the amount of Human XPNPEP2 present. The reaction is stopped by adding an acidic stop solution, and the absorbance is measured at 450 nm.
Catalog No:
BPE233
Regular price
$754.00 USD
Regular price
$580.00 USD
Sale price
$754.00 USD
Unit price
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per
2 weeks
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Product Details
Species Reactivity
Human
Sensitivity
4.21 pg/mL
Detection Range
10.94-700 pg/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
3.5 hour(s)
Research Areas
Cell Biology, Metabolism, Signal Transduction
Background
Aminopeptidase P (APP) is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. A membrane-bound and soluble form of this enzyme (XPNPEP2) have been identified as products of two separate genes. XPNPEP2, the X-linked gene that encodes membranous aminopeptidase P (APP), has been reported to associate with APP activity. The membrane aminopeptidase P (XPNPEP2) is largely limited in distribution to endothelia and brush border epithelia. APP and XPNPEP2 contain homologous blocks of sequence common to members of the "pita bread-fold" protein family, of which Escherichia coli methionine aminopeptidase is the prototype. The C-2399A variant in XPNPEP2 is associated with reduced APP activity and a higher incidence of AE-ACEi. XPNPEP2 mRNA was detected in fibroblasts that carry the translocation, suggesting that this gene at least partially escapes X inactivation. XPNPEP2 is a candidate gene for premature ovarian failure (POF).
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
This product can be stored at 2-8C.
Analyte
Xaa-Pro aminopeptidase 2
Regulatory Status
For Research Use Only
