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Mouse BECN1 (Beclin 1) ELISA Kit
Mouse BECN1 (Beclin 1) ELISA Kit
The Mouse (BECN1) Beclin 1 ELISA Kit measures Beclin 1 in Mouse samples. The plate has been pre-coated with Mouse BECN1 antibody. BECN1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Mouse BECN1 Antibody is added and binds to BECN1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated BECN1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Mouse BECN1. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E1134Mo
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Mouse
Sensitivity
0.017 ng/mL
Detection Range
0.05-15 ng/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Background
Plays a central role in autophagy (PubMed: 10604474, PubMed: 12372286, PubMed: 19270693, PubMed: 28445460). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed: 19270693, PubMed: 25275521). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (PubMed: 25275521). Involved in endocytosis including endosome formation in neuronal cells (PubMed: 25275521). May play a role in antiviral host defense (By similarity). Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors (By similarity). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Beclin 1
Regulatory Status
For Research Use Only
