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Mouse FOXC1 (Forkhead Box Protein C1) ELISA Kit
Mouse FOXC1 (Forkhead Box Protein C1) ELISA Kit
The Mouse (FOXC1) Forkhead Box Protein C1 ELISA Kit measures Forkhead Box Protein C1 in Mouse samples. The plate has been pre-coated with Mouse FOXC1 antibody. FOXC1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Mouse FOXC1 Antibody is added and binds to FOXC1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated FOXC1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Mouse FOXC1. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2079Mo
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Mouse
Sensitivity
0.97 ng/L
Detection Range
2-600 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Background
DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed: 9635428, PubMed: 9106663, PubMed: 10479$458.00|$300.00, PubMed: 10395790, PubMed: 11562355, PubMed: 18187037, PubMed: 19668217, PubMed: 22493429, PubMed: 24590069, PubMed: 25808752, PubMed: 28223138). Acts either as a transcriptional activator or repressor (PubMed: 28223138). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed: 25808752). Upon DNA-binding, promotes DNA bending. Acts as a transcriptional coactivator (PubMed: 25808752). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (PubMed: 25808752). Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (By similarity). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (PubMed: 28223138). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (By similarity). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (PubMed: 18187037). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (By similarity). Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage (PubMed: 9106663, PubMed: 10479$458.00|$300.00, PubMed: 10395790, PubMed: 10704385, PubMed: 11562355, PubMed: 15196959). Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC) (PubMed: 24590069). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner (PubMed: 22171010). May function as a tumor suppressor (By similarity). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Forkhead Box Protein C1
Regulatory Status
For Research Use Only
