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Mouse IL17RA (Interleukin-17 Receptor A) ELISA Kit
Mouse IL17RA (Interleukin-17 Receptor A) ELISA Kit
The Mouse (IL17RA) Interleukin-17 Receptor A ELISA Kit measures Interleukin-17 Receptor A in Mouse samples. The plate has been pre-coated with Mouse IL17RA antibody. IL17RA present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Mouse IL17RA Antibody is added and binds to IL17RA in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated IL17RA antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Mouse IL17RA. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2177Mo
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Mouse
Sensitivity
3.42 ng/L
Detection Range
6-1800 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Cytokines, Inflammation, Immunology
Background
Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed: 17911633, PubMed: 20554964, PubMed: 8777726, PubMed: 27923703). Receptor for IL17F (PubMed: 17911633, PubMed: 20554964). Binds to IL17A with higher affinity than to IL17F (PubMed: 17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (By similarity). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (By similarity). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial Peptides and Matrix Metalloproteinases, with potential strong immune inflammation (By similarity). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (PubMed: 21993848, PubMed: 20364087). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (PubMed: 18157131). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (PubMed: 19144317). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity (PubMed: 27795421). Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (PubMed: 26735852). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed: 21993848, PubMed: 21993849, PubMed: 21982598). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Interleukin-17 Receptor A
Regulatory Status
For Research Use Only
