1
/
of
1
Mouse Interleukin-6 Receptor Subunit Alpha (IL-6RA) ELISA Kit
Mouse Interleukin-6 Receptor Subunit Alpha (IL-6RA) ELISA Kit
This ELISA kit is designed to detect Mouse Interleukin-6 Receptor Subunit Alpha (Mouse IL-6RA). The assay plate has been pre-coated with mouse anti-Mouse IL-6R monoclonal antibody. When the sample containing IL- 6R is added to the plate, it binds to the antibodies coated on the wells. Then, a horseradish peroxidase conjugated mouse anti-Mouse IL-6R Antibody is added to the wells and binds to IL-6R in the sample. After washing the wells, substrate solutions are added, and the color intensity is directly proportional to the amount of Mouse IL-6R present. The reaction is stopped by adding an acidic stop solution, and the absorbance is measured at 450 nm.
Catalog No:
BPE306
Regular price
$624.00 USD
Regular price
$480.00 USD
Sale price
$624.00 USD
Unit price
/
per
2 weeks
Couldn't load pickup availability
Product Details
Species Reactivity
Mouse
Sensitivity
1.15 pg/mL
Detection Range
6.25-400 pg/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
3.5 hour(s)
Research Areas
Neuroscience, Immunology, Stem cells
Background
Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (SIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a SIL-6R protein can mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signaling. Through this so-called 'trans-signaling' mechanism, IL-6 can stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and SIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
This product can be stored at 2-8C.
Analyte
Interleukin-6 receptor subunit alpha
Regulatory Status
For Research Use Only
