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Mouse JAM3 (Junctional Adhesion Molecule C) ELISA Kit
Mouse JAM3 (Junctional Adhesion Molecule C) ELISA Kit
The Mouse (JAM3) Junctional Adhesion Molecule C ELISA Kit measures Junctional Adhesion Molecule C in Mouse samples. The plate has been pre-coated with Mouse JAM3 antibody. JAM3 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Mouse JAM3 Antibody is added and binds to JAM3 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated JAM3 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Mouse JAM3. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2195Mo
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Mouse
Sensitivity
1.63 ng/L
Detection Range
3-900 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
CD & Adhesion molecule
Background
Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed: 15372036, PubMed: 16093349). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed: 24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (PubMed: 16297198). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (PubMed: 15372036, PubMed: 15994945). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed: 16093349). Plays a role in angiogenesis (PubMed: 15994945). Plays a role in the regulation of cell migration (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). [Soluble form of JAM-C]: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis. Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Junctional Adhesion Molecule C
Regulatory Status
For Research Use Only
