The Mouse (LAMP1) Lysosome-associated Membrane Glycoprotein 1 ELISA Kit measures Lysosome-associated membrane glycoprotein 1 in Mouse samples. The plate has been pre-coated with Mouse LAMP1 antibody. LAMP1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Mouse LAMP1 Antibody is added and binds to LAMP1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated LAMP1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Mouse LAMP1. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Research AreasNeuroscience, Stem Cells, Cell Biology
BackgroundLysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. The human LAMP1 gene is located on the long arm (q) of chromosome 13 at region 3, band 4 (13q34). Lysosomal-associated membrane protein 1 is a glycoprotein from a family of Lysosome-associated membrane glycoproteins. The LAMP-1 glycoprotein is a type I transmembrane protein which is expressed at high or medium levels in at least 76 different normal tissue cell types. It resides primarily across lysosomal membranes, and functions to provide selectins with carbohydrate ligands. CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells. and may also play a role in tumor cell differentiation and metastasis. Source: UniProt Consortium (2025)
