The Mouse (PTPN4) Tyrosine-protein Phosphatase Non-receptor Type 4 ELISA Kit measures Tyrosine-Protein Phosphatase Non-Receptor Type 4 in Mouse samples. The plate has been pre-coated with Mouse PTPN4 antibody. PTPN4 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Mouse PTPN4 Antibody is added and binds to PTPN4 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated PTPN4 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Mouse PTPN4. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
BackgroundPhosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed: 17953619, PubMed: 25825441). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (By similarity). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed: 25825441). Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (PubMed: 18614237). May act at junctions between the membrane and the cytoskeleton. Source: UniProt Consortium (2025)
Shipping ConditionShipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
AnalyteTyrosine-Protein Phosphatase Non-Receptor Type 4
