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Mouse Receptor Tyrosine-Protein Kinase Erbb-3 (ERBB3) ELISA Kit
Mouse Receptor Tyrosine-Protein Kinase Erbb-3 (ERBB3) ELISA Kit
This ELISA kit is designed to detect Mouse Receptor Tyrosine-Protein Kinase Erbb-3 (Mouse ERBB3). The assay plate has been pre-coated with mouse anti-Mouse HER3 monoclonal antibody. When the sample containing HER3 is added to the plate, it binds to the antibodies coated on the wells. Then, a horseradish peroxidase conjugated mouse anti-Mouse HER3 Antibody is added to the wells and binds to HER3 in the sample. After washing the wells, substrate solutions are added, and the color intensity is directly proportional to the amount of Mouse HER3 present. The reaction is stopped by adding an acidic stop solution, and the absorbance is measured at 450 nm.
Catalog No:
BPE337
Regular price
$754.00 USD
Regular price
$580.00 USD
Sale price
$754.00 USD
Unit price
/
per
2 weeks
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Product Details
Species Reactivity
Mouse
Sensitivity
9.81 pg/mL
Detection Range
39.06-2500 pg/mL
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
3.5 hour(s)
Research Areas
Cancer, Signal Transduction, Neuroscience
Background
ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form. Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
This product can be stored at 2-8C.
Analyte
Receptor tyrosine-protein kinase erbB-3
Regulatory Status
For Research Use Only
