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Mouse SGPL1 (Sphingosine-1-phosphate Lyase 1) ELISA Kit
Mouse SGPL1 (Sphingosine-1-phosphate Lyase 1) ELISA Kit
The Mouse (SGPL1) Sphingosine-1-phosphate Lyase 1 ELISA Kit measures Sphingosine-1-phosphate lyase 1 in Mouse samples. The plate has been pre-coated with Mouse SGPL1 antibody. SGPL1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Mouse SGPL1 Antibody is added and binds to SGPL1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated SGPL1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Mouse SGPL1. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2486Mo
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
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per
2.5 weeks
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Product Details
Species Reactivity
Mouse
Sensitivity
3.44 ng/L
Detection Range
7-1500 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Background
Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine (PubMed:9464245, PubMed:20097939).
Elevates stress-induced ceramide production and apoptosis (PubMed:9464245).
Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts (PubMed:20097939, PubMed:28262793).
Involved in the regulation of pro-inflammatory response and neutrophil trafficking (PubMed:21173151).
Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (PubMed:28521611).
Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
Sphingosine-1-phosphate lyase 1
Regulatory Status
For Research Use Only
