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Mouse SOCS-1 (Suppressors of Cytokine Signaling 1) ELISA Kit
Mouse SOCS-1 (Suppressors of Cytokine Signaling 1) ELISA Kit
The Mouse (SOCS-1) Suppressors of Cytokine Signaling 1 ELISA Kit measures suppressors of cytokine signaling 1 in Mouse samples. The plate has been pre-coated with Mouse SOCS-1 antibody. SOCS- 1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated Mouse SOCS-1 Antibody is added and binds to SOCS-1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated SOCS-1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of Mouse SOCS-1. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
Catalog No:
E2496Mo
Regular price
$595.00 USD
Regular price
$458.00 USD
Sale price
$595.00 USD
Unit price
/
per
2.5 weeks
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Product Details
Species Reactivity
Mouse
Sensitivity
12.01 ng/L
Detection Range
20-7000 ng/L
Sample Type
Serum, plasma, cell culture supernates
Incubation(s)
1.5 hour(s)
Research Areas
Immunology, Signal Transduction, Epigenetics and Nuclear Signaling, Stem Cells, Cancer, Metabolism
Background
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway (PubMed:15522878).
Through binding to JAKs and IFNGR1, inhibits their kinase activity (PubMed:9202125).
In vitro, also suppresses Tec protein-tyrosine activity (By similarity).
Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF) (PubMed:9202125).
Regulates interferon-gamma (IFNG) mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 (By similarity).
SOCS1 appears to be a negative regulator in IGF1R signaling pathway (By similarity). Source: UniProt Consortium (2025)
Shipping Condition
Shipped on cold gel packs.
Storage Condition and Shelf Life
2-8C
Analyte
suppressors of cytokine signaling 1
Regulatory Status
For Research Use Only
